Thermo Fisher Scientific YAP1 Monoclonal Antibody (OTI9C2)
YAP1 단백질을 인식하는 단클론 항체로 Western blot에 적합. Human 및 Mouse 시료에 반응하며, IgG1 아이소타입. 동결건조 형태로 제공되며 PBS와 트레할로스 함유. Hippo 신호전달 연구 및 암 관련 단백질 분석에 유용.
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 347–504 of human YAP1 (NP_001123617) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
YAP (Yes-Associated Protein) is a transcriptional co-activator and oncogene, belonging to the WW domain family of proteins. It is a key downstream effector of the Hippo signaling pathway, which regulates organ size, proliferation, and apoptosis. YAP is implicated in tissue tension, 3D tissue architecture, cell proliferation, and migration. Dysregulation of YAP activity is associated with tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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