Thermo Fisher Scientific LARP1 Monoclonal Antibody (OTI4E2)
LARP1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 적합합니다. Human, Mouse, Rat 반응성이 있으며, IgG1 아이소타입입니다. 동결건조 형태로 제공되며, PBS와 8% 트레할로스 버퍼에 보관됩니다.
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 315–615 of human LARP1 (NP_291029) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
LARP1 is an RNA-binding protein that regulates translation of specific mRNA species downstream of the mTORC1 complex, depending on growth signals and nutrient availability. It interacts with both the 3′ poly-A tails and the 5′ terminal oligopyrimidine (5′TOP) motif of mRNAs, influencing translation and protein synthesis. Phosphorylation by mTORC1 modulates its binding behavior, impacting cell growth, proliferation, and apoptosis regulation.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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