Thermo Fisher Scientific YAP1 Monoclonal Antibody (OTI5E6)
YAP1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화됨. 인간 및 마우스 반응성, 무보존제 PBS 용액 형태로 제공. Hippo 신호 경로 연구 및 암 관련 단백질 분석에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E6 |
| Immunogen | Human recombinant protein fragment (aa 347–504 of human YAP1, NP_001123617) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
YAP (Yes-Associated Protein) is a transcriptional co-activator and oncogene, belonging to the WW domain family.
It is transcriptionally activated in squamous cell carcinoma cells and functions as both a coactivator and corepressor.
YAP is a critical downstream target in the Hippo signaling pathway, which regulates organ size and tumor suppression by controlling proliferation and apoptosis.
It also plays roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and migration.
Mutations in the IRF5 gene result in coloboma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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