Thermo Fisher Scientific CMG2 Polyclonal Antibody
Anthrax toxin receptor 2(CMG2)을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. Human 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS buffer에 2% sucrose와 0.09% sodium azide가 포함되어 있습니다.
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Applications
- Western Blot (WB): Tested at 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human ANTXR2 (aa 85–134) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608421 |
Product Specific Information
Peptide sequence:
FSSQATIILP LTGDRGKISK GLEDLKRVSP VGETYIHEGL KLANEQIQKA
Sequence homology:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Target Information
Anthrax toxin receptor 2 (ATR2), also known as capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type I membrane protein containing an extracellular von Willebrand factor A (VWA) domain with a MIDAS motif.
It binds to the protective antigen (PA) component of anthrax toxin, facilitating the delivery of edema factor (EF) and lethal factor (LF) into the cytosol.
Mutations in ATR2/CMG2 can inhibit binding by the VWA domain, leading to infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), both rare disorders characterized by hyaline deposition in skin and other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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