Thermo Fisher Scientific NFkB p105 Polyclonal Antibody
NFkB p105 단백항체로 인간 및 생쥐 반응성 확인. Western blot, IHC, ICC/IF, ChIP 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제. 4°C 단기, -20°C 장기 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- PA585292
- 판매단위
- pk
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Thermo Fisher Scientific NFkB p105 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human NFkB p105 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792435 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (91%), Rat (90%), Dog (94%), Pig (93%), Rhesus Monkey (99%), Bovine (92%).
- Positive Control: HeLa, A431.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
NF-kB is a nuclear transcription factor activated by various extra- and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products.
It regulates cellular events including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50) is synthesized as a p105 precursor protein containing an N-terminal RHD region with nuclear localization, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65 to create the functional NF-kB factor, directing nuclear translocation and DNA binding.
NF-kB is implicated in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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