Thermo Fisher Scientific Epiregulin Polyclonal Antibody
Thermo Fisher Scientific의 Epiregulin Polyclonal Antibody는 마우스 Epiregulin을 인식하는 염소 유래 IgG 항체입니다. Western blot 및 중화 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS와 trehalose로 보존되며, 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
- Publications: [참고 문헌 없음]
Neutralization (Neu)
- Tested Dilution: 0.3–1.0 µg/mL
- Publications: [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse Epiregulin (Val56–Leu101) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607378 |
Product Specific Information
- In direct ELISAs, approximately 40% cross-reactivity with recombinant human Epiregulin is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not to ErbB2 or ErbB3. It is mainly expressed in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney, and colon. Epiregulin stimulates proliferation of keratinocytes, hepatocytes, fibroblasts, and vascular smooth muscle cells, while inhibiting growth of several tumor-derived epithelial cell lines.
Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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