Thermo Fisher Scientific SIGLEC5 Polyclonal Antibody

Thermo Fisher Scientific SIGLEC5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 5% cross-reactivity with recombinant human Siglec-7 and Siglec-9 is observed.
• Less than 1% cross-reactivity with Siglec-2 and Siglec-3.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level < 0.10 EU per 1 µg of antibody (LAL method).

Target Information

SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally to α2,3-linked and α2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
This molecule is expressed by monocytic/myeloid lineage cells and found at high levels in peripheral blood leukocytes, spleen, and bone marrow, with lower levels in lymph node, lung, appendix, placenta, pancreas, and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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