Thermo Fisher Scientific SIGLEC5 Polyclonal Antibody
Human SIGLEC5 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot, IHC, Flow cytometry, Neutralization 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 trehalose 완충액에 동결건조 형태로 제공.
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Thermo Fisher Scientific SIGLEC5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL | - |
| Flow Cytometry (Flow) | 2.5 µg per million cells | 1 publication |
| Neutralization (Neu) | 0.5–2.0 µg/mL | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Siglec-5 (Glu17–Thr434) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610347 |
Product Specific Information
- In direct ELISAs, approximately 5% cross-reactivity with recombinant human Siglec-7 and Siglec-9 is observed.
- Less than 1% cross-reactivity with Siglec-2 and Siglec-3.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level < 0.10 EU per 1 µg of antibody (LAL method).
Target Information
SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally to α2,3-linked and α2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
This molecule is expressed by monocytic/myeloid lineage cells and found at high levels in peripheral blood leukocytes, spleen, and bone marrow, with lower levels in lymph node, lung, appendix, placenta, pancreas, and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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