Thermo Fisher Scientific GFAP Polyclonal Antibody

Thermo Fisher Scientific GFAP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

OPA1-06100 detects glial fibrillary acidic protein (GFAP) from human, mouse, zebrafish, and rat tissues.
It has been successfully used in Western blot and immunohistochemistry (paraffin and frozen) procedures.
By Western blot, this antibody detects a single protein representing GFAP in rat brain homogenate.
Immunohistochemical staining of GFAP in rat brain with OPA1-06100 results in intense staining of astrocytes and Schwann cells.
The immunogen is a cytoskeletal preparation of human spinal cord.
Store at 4ºC or in small aliquots at -20ºC.

Target Information

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family.
GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves.
Neural stem cells strongly express GFAP. Antibodies to GFAP are useful as markers of astrocytic cells.
Many types of brain tumor derived from astrocytic cells express GFAP. It is also found in lens epithelium, Kupffer cells of the liver, some salivary tumor cells, and has been reported in erythrocytes.
GFAP is used as a marker to distinguish astrocytes from other glial cells during development.
Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the CNS.
Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.