Thermo Fisher Scientific VEGF Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:200
• View 2 publications

Product Specifications

Product Specific Information

OPA1-10110 detects recombinant human VEGF.
OPA1-10110 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~21 kDa protein representing recombinant human VEGF.
OPA1-10110 immunogen is a synthetic peptide corresponding to residues A(27) P M A E G G G Q N H H E V V K F M D(45) of human VEGF.

Target Information

VEGF (vascular endothelial growth factor) is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis, promoting tumor progression and metastasis.
VEGF affects vascular endothelium by promoting endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability.
The VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF.
VEGF and its receptor system are fundamental regulators of angiogenesis signaling.
Five isoforms of VEGF are generated by alternative splicing from a single VEGF gene, binding to tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), expressed mainly on endothelial cells.
VEGF and its receptors FLK1 and FLT1 are important for embryonic vascular development.
An alternately spliced form of FLT1 produces a soluble protein (sFLT1) that binds VEGF with high affinity, inhibiting angiogenesis.
Elevated VEGF levels are linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes), also known as Crow-Fukase syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.