
Thermo Fisher Scientific S1P1 Polyclonal Antibody
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Applications
Tested Dilution
Publications
Western Blot (WB)
Assay-dependent
View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
Assay-dependent
Product Specifications
Species Reactivity
Human
Published species
Human, Sheep
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, KLH conjugated, corresponding to the C-terminal domain of human S1P1. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
S1P1,
uniProtId:
P21453-1,
ncbiNodeId:
9606,
antigenRange:
382,
antigenLength:
382,
antigenImageFileName:
OPA1-15004_S1P1_P21453-1_Rabbit.svg,
antigenImageFileNamePDP:
OPA1-15004_S1P1_P21453-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2184730
Product Specific Information
Positive Control: Heart, Vessel
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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