Thermo Fisher Scientific CD8b Monoclonal Antibody (CC58), PE

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Product Specific Information

This antibody recognizes an epitope associated with the bovine CD8 beta chain. CD8 is usually expressed as an alpha/beta heterodimer.
This antibody has been successfully used for the immunohistochemical detection of CD8 on formalin-fixed, paraffin-embedded placental tissue from water buffalo.

Reconstitution: Add 1 mL distilled water before use.

Target Information

The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.
CD8 acts as a coreceptor with the T-cell receptor to recognize antigens displayed by antigen-presenting cells (APCs) in the context of class I MHC molecules.
The functional coreceptor can be either a homodimer (two alpha chains) or a heterodimer (one alpha and one beta chain). Both chains share significant homology to immunoglobulin variable light chains.
This gene encodes the CD8 beta chain isoforms, with multiple alternatively spliced transcript variants encoding distinct membrane-associated or secreted isoforms. A pseudogene on chromosome 2 has also been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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