Thermo Fisher Scientific CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), Biotin, eBioscience

Thermo Fisher Scientific CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), Biotin, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 0.25 µg/test
Publications: View 2 publications

Product Specifications

Additional Formats

• Unconjugated
• APC
• eFluor 450
• FITC
• Functional Grade
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Request custom conjugation

Product Specific Information

The TM-b1 monoclonal antibody reacts with mouse CD122, the 90–110 kDa interleukin-2 receptor beta chain (IL-2Rβ). CD122 is expressed by NK cells and some T cells in the periphery, and is upregulated upon activation. It associates with CD25 and CD132 (common gamma chain) to form the high-affinity IL-2 receptor. TM-b1 inhibits high-affinity IL-2 binding to the receptor.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse splenocytes at ≤0.25 µg per test (100 µL final volume, 10⁵–10⁸ cells/test).
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system. It exists in three forms:

• Low affinity: α subunit monomer (non-signaling)
• Intermediate affinity: α/β heterodimer
• High affinity: α/β/γ heterotrimer

Intermediate and high-affinity forms participate in receptor-mediated endocytosis and mitogenic signal transduction. The CD122 gene encodes the β subunit, a type I membrane protein.
Associated Diseases: Oligoarticular juvenile idiopathic arthritis, rheumatoid factor-negative juvenile idiopathic arthritis.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.