Thermo Fisher Scientific ASAP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

ASAP1, also known as Development and Differentiation Enhancing Factor 1, is a protein containing two ANK repeats, an Arf-GAP domain, a PH domain, and an SH3 domain.
It functions as a homodimer interacting with SRC and CRK, with activity stimulated by phosphatidylinositol 4,5-biphosphate (PIP2).
ASAP1 exhibits PIP2-dependent GTPase-activating protein activity for ARF1 and ARF5, and to a lesser extent for ARF6.
It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling and is involved in fibroblast differentiation into adipocytes.
ASAP1 is widely expressed and acts as a proto-oncogene implicated in invasive breast cancer and other malignant tumors, including uveal melanomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.