Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI1G2), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through receptors IL-1RI and IL-1RII, shared with IL-1 beta.
Located on chromosome 2q13, IL-1α plays a key role in innate immune defense by inducing other proinflammatory cytokines and acute-phase responses.
Activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which inhibits receptor binding. IL-1α influences NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 expression, and enhances nitric oxide production.
Elevated IL-1α levels are linked to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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