Thermo Fisher Scientific CREB Recombinant Superclonal Antibody (3HCLC)
CREB 단백질을 인식하는 Thermo Fisher Scientific의 Recombinant Superclonal™ 항체. Western blot 및 ICC/IF에 적합하며, 높은 특이성과 일관된 재현성을 제공. 인간 유래, Expi293 발현, Protein A 정제, 0.5 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:5,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 3HCLC |
| Immunogen | Recombinant protein corresponding to amino acids 222–341 of human CREB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532591 |
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies. Each lot is produced with a defined mixture of light and heavy chains, eliminating biological variability.
Note: Formerly called “Recombinant Polyclonal Antibody”, now rebranded as “Recombinant Superclonal™ Antibody”. The product and performance remain unchanged.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa transcription factor that binds to the cyclic AMP response element (CRE) and activates transcription in response to extracellular signals such as neurotransmitters, hormones, and growth factors. Activation depends on phosphorylation of serine 133 via MAP kinase pathways.
Phosphorylated CREB acts as a transcription factor interacting with CREB binding protein (CBP). CREB plays roles in circadian rhythm regulation, adipocyte differentiation, and learning and memory.
In humans, the CREB gene is located on chromosome 2q. Dysregulation is associated with Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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