Thermo Fisher Scientific IFN gamma Recombinant Polyclonal Antibody (22HCLC)
Thermo Fisher Scientific의 IFN gamma Recombinant Polyclonal Antibody (22HCLC)은 마우스 IFN-γ(aa 23–155)에 대응하는 재조합 항체로, 높은 특이성과 감도를 제공. Western blot 등에 사용 가능하며, 안정적인 로트 간 재현성을 보장. 연구용으로만 사용.
- 카탈로그번호
- 710150
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB)
Tested Dilution
- 0.1–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 22HCLC |
| Immunogen | Recombinant protein corresponding to amino acids 23–155 of mouse IFN-gamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532592 |
Product Specific Information
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific.
They consist of multiple recombinant monoclonal antibodies, combining polyclonal sensitivity with monoclonal specificity.
Each lot is produced with a known mixture of light and heavy chains, ensuring consistent performance and eliminating biological variability typical of traditional polyclonal antibodies.
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor produced primarily by T-lymphocytes and natural killer cells in response to antigens and cytokines.
It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits, functioning as a homodimer.
On SDS-PAGE, IFN gamma shows 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
Human IFN gamma does not cross-react with mouse.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of class I and II MHC
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
IFN gamma acts via the JAK-STAT pathway through receptors I and II.
It shares ~40% sequence homology between human and mouse forms.
Upregulated by IL2, FGF basic, and EGF; downregulated by vitamin D3 or DMN.
Mutations in the IFN gamma gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 710150_IFN_gamma_P01580-1_Rabbit.svg, 710150_IFN_gamma_P01580-1_Rabbit_PDP.jpeg)
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