Thermo Fisher Scientific IFN gamma Recombinant Polyclonal Antibody (22HCLC)

Applications

• Western Blot (WB)

Tested Dilution

• 0.1–1 µg/mL

Product Specifications

Product Specific Information

Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific.
They consist of multiple recombinant monoclonal antibodies, combining polyclonal sensitivity with monoclonal specificity.
Each lot is produced with a known mixture of light and heavy chains, ensuring consistent performance and eliminating biological variability typical of traditional polyclonal antibodies.

Target Information

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor produced primarily by T-lymphocytes and natural killer cells in response to antigens and cytokines.
It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits, functioning as a homodimer.
On SDS-PAGE, IFN gamma shows 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
Human IFN gamma does not cross-react with mouse.
Functions include:

• Antiviral and tumor antiproliferative activity
• Induction of class I and II MHC
• Macrophage activation
• Enhanced immunoglobulin secretion by B lymphocytes

IFN gamma acts via the JAK-STAT pathway through receptors I and II.
It shares ~40% sequence homology between human and mouse forms.
Upregulated by IL2, FGF basic, and EGF; downregulated by vitamin D3 or DMN.
Mutations in the IFN gamma gene are associated with aplastic anemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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