Thermo Fisher Scientific DACH1 Polyclonal Antibody
DACH1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, IP 등 다양한 실험에 사용 가능. Rabbit IgG 기반, 액상 형태, 4°C 보관. 인간 DACH1의 708–758번 영역을 면역원으로 사용하며, 마우스와도 반응 예측됨.
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Thermo Fisher Scientific DACH1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 708 and 758 of human Dachshund Homolog 1 (DACH1, UniProt ID: Q9UI36-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Transcription factor involved in regulation of organogenesis.
Acts as a regulator of SIX1, SIX6, and possibly SIX5.
Switches SIX1-mediated repression to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex.
Transcriptional activation involves association with CREBBP.
Acts as a corepressor of SIX6 by repressing cyclin-dependent kinase inhibitors such as p27Kip1.
Inhibits TGF-beta signaling via interaction with SMAD4 and NCOR1.
Binds chromatin DNA through its DACHbox-N domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: A303-556A-M_DACH1_Q9UI36-1_Rabbit.svg, A303-556A-M_DACH1_Q9UI36-1_Rabbit_PDP.jpeg)
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