Thermo Fisher Scientific DACH1 Polyclonal Antibody
DACH1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB·IHC·IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상형 항체이며, Human에 반응. 연구용으로만 사용 가능.
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Thermo Fisher Scientific DACH1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 708 and 758 of human Dachshund Homolog 1 (DACH1, UniProt ID: Q9UI36-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
DACH1 is a transcription factor involved in organogenesis regulation. It acts as a regulator of SIX1, SIX6, and possibly SIX5. DACH1 modulates transcriptional activity through interactions with EYA3 and CREBBP, functioning as a corepressor or coactivator depending on context. It represses cyclin-dependent kinase inhibitors (e.g., p27Kip1 promoter) and inhibits TGF-beta signaling via interaction with SMAD4 and NCOR1. DACH1 binds chromatin DNA through its DACHbox-N domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: A303-556A_DACH1_Q9UI36-1_Rabbit.svg, A303-556A_DACH1_Q9UI36-1_Rabbit_PDP.jpeg)
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