Thermo Fisher Scientific Kaiso Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, binding both methylated CGCG and non-methylated KAISO-binding site TCCTGCNA. The protein includes an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and repressive chromatin formation in target gene promoters. It may repress Wnt signaling pathway target genes or activate transcription of certain genes via catenin delta-2 (CTNND2) recruitment. Interaction with catenin delta-1 (CTNND1) inhibits DNA binding. It also interacts with Importin-alpha 2 (karyopherin alpha2), mediating nuclear import. Alternatively spliced transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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