Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Dectin-2 단백질을 인식하는 Sheep Polyclonal 항체로, Western Blot 및 IHC에 사용 가능. 인간 시료 반응성. 합성 펩타이드 항원으로 제작되었으며, PBS 내 동결건조 상태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human Dectin 2 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Dectin-2.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 specifically recognizes high mannose structures and mediates cytokine production from dendritic cells and other antigen-presenting cells.
Although Dectin-2 lacks obvious signaling motifs, it utilizes FcRγ for internalization and activation of the NF-κB pathway, leading to cytokine production. Despite sharing only 20–25% homology with Dectin-1, Dectin-2 functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk–CARD9 pathway) and adaptive immune responses via dendritic cell activation. Thus, Dectin-2 serves as a connector molecule linking innate and adaptive immunity at the dendritic cell level.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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