Thermo Fisher Scientific Dectin 2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Dectin-2.

Target Information

Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 specifically recognizes high mannose structures and mediates cytokine production from dendritic cells and other antigen-presenting cells.

Although Dectin-2 lacks obvious signaling motifs, it utilizes FcRγ for internalization and activation of the NF-κB pathway, leading to cytokine production. Despite sharing only 20–25% homology with Dectin-1, Dectin-2 functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk–CARD9 pathway) and adaptive immune responses via dendritic cell activation. Thus, Dectin-2 serves as a connector molecule linking innate and adaptive immunity at the dendritic cell level.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.