Thermo Fisher Scientific DRAM Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and shares 86% identity with human.
• Specificity: DRAM.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, together promoting a full cell death response.
DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests that autophagy may play a more significant role in cancer than initially suspected.
At least two isoforms of DRAM are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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