Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Thermo Fisher Scientific의 Dectin 2 Polyclonal Antibody는 인간 Dectin-2 단백질을 인식하는 양에서 유래한 Ig 폴리클로날 항체입니다. Western blot 및 IHC에 사용 가능하며, 면역세포의 Dectin-2 신호 전달 연구에 적합합니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publication: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human Dectin-2 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Dectin-2.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain.
Dectin-2 recognizes high mannose structures and mediates cytokine production from dendritic cells and other antigen-presenting cells. Although it lacks obvious signaling motifs, Dectin-2 employs FcRγ for internalization and activation of the NF-κB pathway.
Dectin-2 shares 20–25% homology with Dectin-1 but functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk–CARD9 pathway) and adaptive immune responses.
Thus, Dectin-2 acts as a connector molecule between innate and adaptive immunity at the dendritic cell level.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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