Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Rabbit polyclonal antibody against human Dectin-2 for WB and IHC applications. Recognizes C-type lectin receptor involved in immune response. Lyophilized form, reconstitute in sterile water. Suitable for research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human Dectin-2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Dectin-2.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain.
Dectin-2 recognizes high mannose structures and mediates cytokine production from dendritic cells and other antigen-presenting cells.
Although Dectin-2 lacks obvious signaling motifs, it interacts with FcRγ to activate the NF-κB pathway for cytokine production.
Despite sharing only 20–25% homology with Dectin-1, Dectin-2 functions as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk–CARD9 pathway) and adaptive immune responses.
Thus, Dectin-2 serves as a connector molecule between innate and adaptive immunity at the dendritic cell level.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: OSD00009G-500UG_Dectin_2_Q6EIG7-1_Rabbit.svg, OSD00009G-500UG_Dectin_2_Q6EIG7-1_Rabbit_PDP.jpeg)
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