Thermo Fisher Scientific AXIN1 Monoclonal Antibody (K.53.7)
AXIN1 단백질을 인식하는 Rabbit monoclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(P), IP에 적합하며, WNT 신호전달 경로 연구에 유용합니다. 고순도 친화 크로마토그래피 정제 제품으로, -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.53.7 |
| Immunogen | Recombinant human Axin1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 40 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10983298 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
AXIN1 is a cytoplasmic protein that contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain. It functions as a negative regulator of the WNT signaling pathway involved in embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, and glycogen synthase kinase 3 beta to form a tetrameric complex that regulates beta-catenin stabilization. Mutations in the AXIN1 gene have been associated with various carcinomas, suggesting a tumor suppressor role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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