Thermo Fisher Scientific AXIN1 Monoclonal Antibody (T.618.2)
AXIN1 단백질을 인식하는 Rabbit 모노클로날 항체로, WB, IHC, IP에 적합합니다. 인간, 마우스, 비인간 영장류 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. WNT 신호 경로 연구 및 종양 억제 관련 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.618.2 |
| Immunogen | Recombinant protein of human Axin1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 140 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10983681 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
AXIN1 is a cytoplasmic protein containing a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain. It functions as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, and glycogen synthase kinase 3 beta, forming a tetrameric complex that regulates beta-catenin stabilization. Mutations in the AXIN1 gene are associated with various carcinomas, suggesting a tumor suppressor role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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