Thermo Fisher Scientific CD93 (AA4.1) Monoclonal Antibody (AA4.1), Biotin, eBioscience
Thermo Fisher Scientific의 CD93 (AA4.1) Biotin 결합 단클론 항체로, 마우스 C1qRp를 인식하며 초기 B세포 발달 단계 연구에 활용됩니다. Flow cytometry에 최적화되어 있으며, 0.25 µg/test로 사용 가능합니다. Affinity chromatography로 정제된 고품질 항체입니다.
- 카탈로그번호
- 13-5892-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD93 (AA4.1) Monoclonal Antibody (AA4.1), Biotin, eBioscience
Applications
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg/test
- View 14 publications
Functional Assay (Functional)
- Tested Dilution: -
- View 1 publication
Miscellaneous PubMed (Misc)
- Tested Dilution: -
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Recommended Isotype Control | Rat IgG2b kappa Isotype Control (eB149/10H5), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AA4.1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466767 |
| Filtration | 0.2 µm post-manufacturing filtered |
Additional Formats
- APC
- eFluor 450
- FITC
- PE
- PE-Cyanine7
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
The AA4.1 monoclonal antibody reacts with mouse C1qRp, a 130–140 kDa C-type lectin-like type I transmembrane protein. The AA4.1 antigen was originally identified on early stages of B cell development in bone marrow. Adult spleen and fetal liver also have detectable numbers of AA4.1⁺ cells.
In combination with other hematopoietic progenitor markers (Thy-1, Sca-1, c-Kit, CD43, CD24), bone marrow Lymphoid-Committed Progenitors (CLP) can be subdivided based on AA4.1 expression.
Surface IgM (sIgM), CD23, and AA4.1 expression define three nonproliferative immature/transitional B cell subsets:
- T1 (AA4.1⁺ / CD23⁻ / sIgM^hi)
- T2 (AA4.1⁺ / CD23⁺ / sIgM^hi)
- T3 (AA4.1⁺ / CD23⁺ / sIgM^lo)
AA4.1 is also expressed in cytoplasmic vesicles of endothelial cells, megakaryoblasts, and platelets. Monoclonal antibodies AA4.1 and 493 recognize different epitopes of the same molecule.
Applications Reported: Flow cytometric analysis
Applications Tested: Flow cytometric analysis of mouse bone marrow and splenocyte cells.
Recommended usage ≤ 0.25 µg/test (100 µL final volume, 10⁵–10⁸ cells/test). Optimize antibody titration for best results.
Target Information
The encoded protein is a cell-surface glycoprotein and type I membrane protein originally identified as a myeloid cell-specific marker. It was initially thought to be a receptor for C1q but is now known to be involved in intercellular adhesion and apoptotic cell clearance.
The cytoplasmic tail interacts with moesin, linking transmembrane proteins to the cytoskeleton and aiding cytoskeletal remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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