Thermo Fisher Scientific Mesothelin Recombinant Mouse Monoclonal Antibody (20-10)
Recombinant mouse monoclonal antibody specific for human Mesothelin (clone 20-10). Suitable for WB, ELISA, and IP. Expressed in HEK293 cells, purified by Protein A. Unconjugated form, 1 mg/mL in PBS with 0.02% ProClin 300. For research use only.
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Applications
- Western Blot (WB): Assay-dependent
- ELISA (ELISA): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 20-10 |
| Immunogen | The original antibody was generated by intraperitoneally immunizing BALB/c mice with the purified recombinant megakaryocyte potentiating factor protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds the human megakaryocyte-potentiating factor.
Target Information
Mesothelin was originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas. It is a GPI-anchored cell-surface glycoprotein predominantly secreted by mesothelial cells.
Although expressed at restricted levels in normal pleural, pericardial, and peritoneal mesothelial cells, aberrant expression occurs in various cancers including endometrioid uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix.
Proteolytic cleavage of Mesothelin yields a soluble fragment known as megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony-forming activity in murine bone marrow cultures. MPF may play roles in megakaryocyte proliferation, differentiation, and platelet production.
High expression levels of Mesothelin and MPF in tumor tissues compared to normal tissues suggest involvement in tumorigenesis, promoting tumor cell proliferation, migration, anchorage-independent growth, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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