Thermo Fisher Scientific CD89 Recombinant Mouse Monoclonal Antibody (14A8 (14.1))
CD89 단백질에 특이적으로 결합하는 재조합 마우스 단클론 항체로, Flow Cytometry, ELISA, IP, Functional Assay에 사용 가능. HEK293 세포에서 발현된 IgG1, kappa 형 항체이며, Protein A로 정제됨. PBS 용액 형태로 제공되며, 연구용으로만 사용.
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Thermo Fisher Scientific CD89 Recombinant Mouse Monoclonal Antibody (14A8 (14.1))
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 14A8 (14.1) |
| Immunogen | The original antibody was generated by immunizing HCO12 transgene-containing mice with recombinant soluble CD89 antigen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds CD89 in the extracellular domain 2, outside the IgA-binding site.
Target Information
CD89 is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA.
This transmembrane glycoprotein is expressed on myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils.
It mediates immunologic responses to pathogens by interacting with IgA-opsonized targets and triggering defense mechanisms including:
- Phagocytosis
- Antibody-dependent cell-mediated cytotoxicity
- Release of inflammatory mediators
Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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