Thermo Fisher Scientific VISTA Recombinant Armenian Hamster Monoclonal Antibody (MH5A)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody specifically binds PD-1H.

Target Information

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells.
VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.