Thermo Fisher Scientific IL2RG Recombinant Rat Monoclonal Antibody (3E12)
IL2RG 단백질을 인식하는 쥐 반응성 재조합 랫트 단클론 항체. Flow Cytometry, IP, Inhibition Assay에 사용 가능. HEK293 발현, Protein A 정제, 1 mg/mL 농도. IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 수용체 복합체의 공통 감마체인에 결합.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3E12 |
| Immunogen | Lewis rats immunised with transfected rat myeloma cell line YB2/0 expressing murine cytoplasmic-tailless IL-2R common gamma-chain (YB2/0-myt) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
This conformation-dependent antibody binds to the murine common gamma-chain, shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptor complexes. It recognises an epitope located in a membrane-proximal portion of the common gamma-chain, near Arg-197 of domain 2. This antibody does not cross-react with COS7 cells transfected with rat common gamma-chain cDNA.
Target Information
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin-2, -4, -7, and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID) as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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