Thermo Fisher Scientific ITGB1 Recombinant Mouse Monoclonal Antibody (K20)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Recognises human CD29.

Target Information

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cells including all leucocytes.
ITGB1 forms non-covalently linked heterodimers with at least six different alpha chains (alpha1–alpha6, CDa–f), determining the binding properties of beta1 (VLA) integrins.
It acts as a cell adhesion molecule on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of protein complexes binding to extracellular matrix proteins.

Decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. It is up-regulated in leukocytes during emigration and extravascular migration, playing a critical role in immune cell trafficking from blood to tissue.
ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1β.

More than eight beta subunits with numerous splice variants have been identified in mammals. Two major forms of integrin beta1—beta1A and beta1D—differ by 13 amino acids. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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