Thermo Fisher Scientific CD27 Monoclonal Antibody (LT27)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 2 µg/mL
• Publications: View 1 publication

Product Specifications

Additional Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD27 (T14), a 50–55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes, and NK cells.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. TNF superfamily members regulate cell proliferation and death.
Expression of CD27 and its ligand CD70 is mainly confined to lymphocytes. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells.
T cell activation via the TCR-CD3 complex upregulates CD27 expression and leads to the release of soluble CD27 (sCD27), a 28–32 kDa form detectable in plasma, urine, or spinal fluid.
Soluble CD27 serves as a prognostic marker for acute and chronic B cell malignancies. CD27-binding protein (SIVA) is involved in CD27-mediated apoptosis.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.