Thermo Fisher Scientific CD14 Monoclonal Antibody (OTI9C7), TrueMAB
인간 CD14 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 유세포분석에 사용 가능. 동결건조 형태이며, 재구성 후 1 mg/mL 농도로 사용. PBS(pH 7.3, 8% 트레할로스) 완충액에 보존되며, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–87 of human CD14 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein expressed on mature monocytes, macrophages, and neutrophils. It functions as a multifunctional lipopolysaccharide receptor and is released into serum as both secreted and cleaved forms. CD14 binds lipopolysaccharides via lipopolysaccharide-binding protein (LBP) and participates in immune recognition and inflammatory responses. Soluble CD14 (sCD14) can differentiate structural variations in lipopolysaccharides and contributes to neutralization of serum endotoxins. Additionally, CD14 binds apoptotic cells and is involved in allergic, inflammatory, and infectious processes.
Alternative splicing produces multiple transcript variants encoding the same isoform.
Diseases associated with CD14 dysfunction include Mycobacterium chelonae infection and croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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