Thermo Fisher Scientific Phospho-SMC1 (Ser957) Recombinant Rabbit Monoclonal Antibody (ARC1606)
Phospho-SMC1 (Ser957) 항체로 인간, 마우스, 랫트 시료에 반응. Western blot, IHC, ELISA에 적합. HEK293 세포 발현의 재조합 단클론 항체로 높은 특이성과 재현성 제공. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1606 |
| Immunogen | A synthetic phosphorylated peptide around S957 of human SMC1 (Q14683) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849790 |
Product Specific Information
Immunogen sequence: GSSQG
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins are crucial for nuclear events involving chromosome structure, such as mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression. These proteins are conserved in eukaryotes and mutations can cause mitotic chromosome segregation defects, indicating their essential role in chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression and sister chromatid cohesion. Mutations in SMC1 can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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