Thermo Fisher Scientific Amyloid Precursor Protein Monoclonal Antibody (LN27)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

View 27 publications 27 publications

Immunohistochemistry (IHC)

5-10 µg/mL

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

-

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

-

View 10 publications 10 publications

ELISA (ELISA)

0.1-0.5 µg/mL

View 4 publications 4 publications

Immunoprecipitation (IP)

-

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

-

View 15 publications 15 publications

Product Specifications

Species Reactivity

Human

Published species

Hamster, Human, Mouse, Non-human primate, Rabbit

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

LN27

Immunogen

Rec-beta-amyloid precursor protein (beta-APP 695)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

purified

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532993

Target Information

Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimers disease. Abnormal regulation and processing of APP also plays a role in Downs syndrome, early onset familial Alzheimer`s disease, and cerebral hemorrhage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.