Thermo Fisher Scientific Zap-70 Monoclonal Antibody (ZAP-70-6F7)
ZAP-70 단백질을 타깃으로 하는 Mouse IgG1 단클론 항체로, 인간 및 생쥐 반응성을 보입니다. Western blot, ICC/IF, ELISA, IP 등 다양한 응용에 사용 가능하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 130600
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Zap-70 Monoclonal Antibody (ZAP-70-6F7)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
| Miscellaneous PubMed | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZAP-70-6F7 |
| Immunogen | Peptide derived from amino acids 326–341 of human ZAP-70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532997 |
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family. It is expressed exclusively in T-cells and natural killer cells and is essential for T-cell receptor activation. Upon T-cell antigen receptor (TCR) engagement, ZAP-70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region between the SH2 and kinase domains.
Phosphorylation of tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances ZAP-70 function in lymphocyte signaling, while phosphorylation at tyrosine 292 terminates transient activation and attenuates signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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