Thermo Fisher Scientific Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (J18), FITC
Phospho-alpha Synuclein (Ser129) 검출용 FITC 결합 리컴비넌트 토끼 단클론 항체. 인간 및 생쥐 반응성, HEK293 발현 시스템 사용. WB, IHC, ICC/IF, ELISA 등 다양한 응용 가능. 형광 최대치 498/517 nm, 4°C 암소 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (J18), FITC
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| ELISA | Assay-dependent |
| Dot blot (DB) | 1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | J18 |
| Immunogen | Human alpha synuclein AA 124–134: AYEMP-pS-EEGYQ-Cys |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 9.09 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932385 |
Available Formats
- APC (Cat. MA5-45930)
- PerCP (Cat. MA5-45932)
- Custom conjugation available upon request
Product Specific Information
- A 1:500 dilution of MA5-45931 was sufficient for detection of Alpha Synuclein pSer129 in 10 µg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
- Binds to phosphorylated serine 129 on alpha synuclein.
- Does not detect unphosphorylated serine 129 alpha synuclein.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.