Thermo Fisher Scientific Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AH36), APC

Applications and Tested Dilution

Product Specifications

Additional Formats

• FITC (Cat. MA5-45934)
• PerCP (Cat. MA5-45935)
• Custom conjugation available upon request

Product Specific Information

A 1:500 dilution of MA5-45933 was sufficient for detection of Tau in 10 µg Baculovirus by dot blot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody. Detects approximately 79 kDa.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both. Tau localization determines axonal polarity in neurons. Short isoforms provide cytoskeletal plasticity, while longer isoforms contribute to stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer’s disease (AD). Hyper-phosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other CNS disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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