Thermo Fisher Scientific AKT1 Monoclonal Antibody (14E5.A2.B2.H9), APC

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• PE
• Custom conjugation available

Product Specific Information

• Store vial at 4°C prior to restoration.
• Restore with deionized water or equivalent.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.
• Centrifuge if not completely clear after standing at room temperature.
• For extended storage, aliquot and freeze at -20°C or below.
• Avoid freeze/thaw cycles.
• Store reagent in the dark; use subdued lighting during handling and incubation.

Anti-AKT1 antibody is directed against human AKT1. The antibody detects both unphosphorylated and phosphorylated forms of the protein. Cross-reactivity with AKT1 from other species has not been determined, but the immunogen sequence shows 85% identity to mouse and 92% identity to rat, suggesting expected cross-reactivity.

Target Information

AKT1 (PKB alpha) is a serine/threonine kinase regulating cell survival. It inhibits apoptosis and promotes cell cycle progression by phosphorylating multiple targets in various cell types, including cancer cells. Activated by insulin, PI3K, IGF1, and other growth factors, Akt promotes survival by inactivating targets such as forkhead transcription factors and caspase-9. The AKT pathway is a major focus in cancer drug discovery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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