Thermo Fisher Scientific Nectin 1 Monoclonal Antibody (R1.302), PE
인간 CD111(Nectin 1)을 인식하는 단클론 항체로, PE 형광표지되어 유세포분석에 적합합니다. 세포 간 접착 관련 연구에 활용되며, 액상 형태로 제공됩니다. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R1.302 |
| Immunogen | Human CD111-transfected NIH/3T3 cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745552 |
Additional Formats
- Unconjugated: MA5-28594
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes an extracellular epitope on CD111 (Nectin 1), a 75 kDa type I transmembrane glycoprotein broadly expressed on endothelial cells, epithelial cells, neuronal cells, megakaryocytes, and CD34-positive stem cells.
Recommended dilution is for 100 µL of whole blood or 1×10⁶ cells in suspension.
Target Information
The gene encodes an adhesion protein involved in the organization of adherens and tight junctions in epithelial and endothelial cells. It is a calcium-independent cell–cell adhesion molecule of the immunoglobulin superfamily, containing three extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region.
This protein serves as a receptor for glycoprotein D of herpes simplex viruses (HSV-1, HSV-2) and pseudorabies virus, mediating viral entry into epithelial and neuronal cells. Mutations in this gene are associated with cleft lip and palate/ectodermal dysplasia 1 syndrome and non-syndromic cleft lip with or without cleft palate.
Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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