Thermo Fisher Scientific TADA2L Polyclonal Antibody
Thermo Fisher Scientific의 TADA2L Polyclonal Antibody는 인간, 생쥐, 랫트, 비인간 영장류에 반응하며 Western blot 및 Immunocytochemistry에 적합합니다. Rabbit IgG 기반 비결합 항체로, PBS/glycerol buffer에 보관되며 chromatin remodeling 관련 연구에 활용됩니다.
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- PA5104485
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Non-human primate, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TADA2A (Accession O75478), corresponding to amino acid residues R218–K268 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853786 |
Product Specific Information
Antibody detects endogenous levels of total ADA2L.
Target Information
TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-alpha) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as two alternatively spliced isoforms. It is most abundantly expressed in testis but is present in all tissues.
TADA2L contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows it to play a role in chromatin remodeling.
TADA2L is part of both the PCAF complex and the ATAC complex, which possess histone acetyltransferase activity on histones H3 and H4.
The gene encoding TADA2L spans 71,408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome, and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia, and Shwachman-Diamond syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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