Thermo Fisher Scientific TADA2L Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ADA2L.

Target Information

TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-alpha) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as two alternatively spliced isoforms. It is most abundantly expressed in testis but is present in all tissues.
TADA2L contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows it to play a role in chromatin remodeling.
TADA2L is part of both the PCAF complex and the ATAC complex, which possess histone acetyltransferase activity on histones H3 and H4.
The gene encoding TADA2L spans 71,408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome, and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia, and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.