Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI3A6), TrueMAB
MDM4 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC/IF에 사용 가능. Human 시료 반응성, Lyophilized 형태로 제공되며, 고순도 Affinity chromatography 정제. 연구용으로 p53 경로 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A6 |
| Immunogen | Full-length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MDM2 is the primary regulator of p53 protein stability. MDMX (also known as MDM4) inhibits MDM2-mediated degradation of p53 through distinct interactions. The MDMX gene is often amplified in malignant gliomas.
ARF interacts with MDMX to sequester it in the nucleolus, increasing p53 transactivation. MDMX expression can counteract MDM2-mediated p53 degradation while maintaining suppression of p53 activity.
Like MDM2, MDMX also binds and stabilizes p73, increasing its half-life in contrast to p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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