Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI4G1)
CD137(TNFRSF9) 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot과 유세포분석에 최적화. 인간 시료 반응성. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G1 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule mainly expressed on activated T cells.
Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports survival and expansion of activated and memory T cells while regulating myelopoiesis and dendritic cell development.
Activation of CD137 induces cytokine release that influences peripheral monocyte survival.
Soluble forms of CD137 may serve as a negative regulator of immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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