Thermo Fisher Scientific TLR5 Monoclonal Antibody (4G5)
TLR5 단백질을 인식하는 Mouse monoclonal antibody (Clone 4G5). Western blot 및 ELISA에 사용 가능하며 인간 시료 반응성. 액상 형태, 보존제 없음, -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific TLR5 Monoclonal Antibody (4G5)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- ELISA: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G5 |
| Immunogen | TLR5 (NP_003259, 517–634 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LPPGVFSHLT ALRGLSLNSN RLTVLSHNDL PANLEILDIS RNQLLAPNPD VFVSLSVLDI THNKFICECE LSTFINWLNH TNVTIAGPPA DIYCVYPDSF SGVSLFSLST EGCDEEEV
Target Information
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family and participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and inflammatory response.
TLR5 is highly expressed in liver, detected in lung, and at very low levels in most other tissues. The TLR5 gene locus is associated with susceptibility to Salmonella. Mouse strains differ in resistance to S. typhimurium:
- Susceptible: BALB/c, C57BL/6, C3H/He
- Intermediate: DBA/2, C75L
- Resistant: A, CBA
Strain MOLF/Ei is highly susceptible, has a unique TLR5 haplotype, and lower expression of TLR5. A common TLR5 stop codon polymorphism disrupting TLR5 signaling is linked to susceptibility to Legionnaires’ disease, highlighting the importance of TLR5 in innate immunity.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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