Thermo Fisher Scientific TLR5 Monoclonal Antibody (4G5)

Thermo Fisher Scientific TLR5 Monoclonal Antibody (4G5)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• ELISA: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
LPPGVFSHLT ALRGLSLNSN RLTVLSHNDL PANLEILDIS RNQLLAPNPD VFVSLSVLDI THNKFICECE LSTFINWLNH TNVTIAGPPA DIYCVYPDSF SGVSLFSLST EGCDEEEV

Target Information

TLR5 is a Type I membrane protein belonging to the Toll-like receptor family and participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and inflammatory response.

TLR5 is highly expressed in liver, detected in lung, and at very low levels in most other tissues. The TLR5 gene locus is associated with susceptibility to Salmonella. Mouse strains differ in resistance to S. typhimurium:

• Susceptible: BALB/c, C57BL/6, C3H/He
• Intermediate: DBA/2, C75L
• Resistant: A, CBA

Strain MOLF/Ei is highly susceptible, has a unique TLR5 haplotype, and lower expression of TLR5. A common TLR5 stop codon polymorphism disrupting TLR5 signaling is linked to susceptibility to Legionnaires’ disease, highlighting the importance of TLR5 in innate immunity.

Usage

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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