Thermo Fisher Scientific Aurora A Recombinant Rabbit Monoclonal Antibody (ST46-07)
Aurora A 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow cytometry에 사용 가능. 높은 특이성과 일관된 로트 품질 제공. 단백질 A 정제, 액상 형태로 4°C 또는 -20°C 보관.
- 카탈로그번호
- MA532146
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST46-07 |
| Immunogen | Synthetic peptide within Human Aurora A (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809436 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by associating with centrosomes. Overexpression is observed in various cancers.
Functions include:
- Regulation of mitosis during anaphase and telophase
- Centrosome/spindle pole function during chromosome segregation
- Key role in tumor development and progression
Tissue specificity: Highly expressed in testis; weakly in skeletal muscle, thymus, and spleen.
Aurora A is considered a potential target for anticancer drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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