Thermo Fisher Scientific MTM1 Polyclonal Antibody
MTM1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 ELISA에 적합하며, 인간과 생쥐 시료에서 반응합니다. 액상 형태로 제공되며, -20°C에서 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific MTM1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 484–603 of human MTM1 (NP_0002431) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.45 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804114 |
Product Specific Information
- Immunogen sequence:
SARERQKVTE RTVSLWSLIN SNKEKFKNPF YTKEINRVLY PVASMRHLEL WVNYYIRWNP RIKQQQPNPV EQRYMELLAL RDEYIKRLEE LQLANSAKLS DPPTSPSSPS QMMPHVQTHF - Positive Samples: Mouse liver, NCI-H460
- Cellular Location: Cell membrane, Cell projection, Cytoplasm, Late endosome, Peripheral membrane protein, filopodium, ruffle
Target Information
Human MTM1 is a 603 amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is associated with recessive Charcot-Marie-Tooth neuropathy. Myotubularin functions as a lipid phosphatase acting on phosphatidylinositol 3-monophosphate and plays a role in PI 3-kinase pathway regulation and membrane trafficking. Wild-type myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-87393_MTM1_Q13496-1_Rabbit.svg, PA5-87393_MTM1_Q13496-1_Rabbit_PDP.jpeg)
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