Thermo Fisher Scientific TRAIL-R2 (DR5) Recombinant Mouse Monoclonal Antibody (TRA-8)
인간 DR5에 특이적인 재조합 마우스 단클론 항체로, Western blot, Flow cytometry, ELISA, 기능적 분석에 사용 가능. HEK293 세포에서 발현되며 Protein A로 정제됨. 연구용으로만 사용, 진단 목적 불가.
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Thermo Fisher Scientific TRAIL-R2 (DR5) Recombinant Mouse Monoclonal Antibody (TRA-8)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TRA-8 |
| Immunogen | The antibody was raised by immunizing BALB/c mice with a fusion protein containing the extracellular portion of human DR5 and the Fc portion of human IgG1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074567 |
Product Specific Information
Specificity: The antibody is specific to human DR5 and does not bind other TRAIL receptors, other members of the TNF-receptor superfamily, or the murine homolog of DR5.
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis. It belongs to the TNF-receptor superfamily and contains an intracellular death domain. Activation by TNFSF10/TRAIL/APO-2L transduces apoptosis signals. FADD-deficient mouse studies indicate FADD is essential for DR5-mediated apoptosis. Two transcript variants encoding different isoforms and one non-coding transcript exist. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in various cell types, with high levels in lymphocytes and spleen. DR5 dysfunction is linked to squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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