Thermo Fisher Scientific Phospho-MEK1 (Thr292) Recombinant Rabbit Monoclonal Antibody (SD2088)
Phospho-MEK1 (Thr292)를 인식하는 재조합 토끼 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태입니다. 인간 MEK1 Thr292 주변 인산화 펩타이드를 면역원으로 사용했습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD2088 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Thr292 of Human MEK1 (aa 271–320) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809650 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in MAPK cascades, controlling cell growth and differentiation. It is activated by various growth factors, cytokines, and membrane-dependent signals.
Phosphorylation of serine 218 and 222 residues by Raf1 activates MEK1. This kinase is involved in stress response, apoptosis, and proliferative induction by cytokines. Mutations in MAP2K1 can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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