Thermo Fisher Scientific ACVR1B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: SK-N-SH, mouse brain
• Predicted reactivity: Mouse (99%), Rat (100%), Xenopus laevis (96%), Pig (100%), Rhesus Monkey (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.
ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and polyadenylation result in 3 described transcript variants. A potential fourth variant contains an alternative exon 8 and lacks exons 9–11, but its mRNA expression has not been confirmed.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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