Thermo Fisher Scientific NOTCH3 Polyclonal Antibody
Thermo Fisher Scientific의 NOTCH3 Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot, IHC, ICC/IF에 적합합니다. KLH 결합 합성 펩타이드로부터 유래한 rabbit IgG 항체로, 세포 운명 결정 관련 NOTCH3 단백질 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 2291–2321 amino acids from the C-terminal region of human NOTCH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion - Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2235931 |
Product Specific Information
This antibody is predicted to react with human based on sequence homology.
Target Information
NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway essential for neural development.
Human homologues of these ligands have also been identified.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1, regulating cell-fate determination.
Mutations in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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